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# Domarin Khago, Ph\.D\.

**Headline:** R&D Program Manager \| Research Operations \| Structural Biophysicist \| AI & Biotech
**Profession:** Director Program Management
**Location:** Oakland, California, United States

## About

Domarin Khago, Ph\.D\., is Director of Program Management at Animate Biosciences, Inc\., where he leads research operations for AnimateIQ, a proprietary AI\-driven research platform\. He coordinates cross\-functional teams from computational design through experimental validation in one\-month research cycles, manages preclinical CRO relationships, and maintains program, milestone, and research\-initiative tracking across active workstreams\. Domarin’s strengths span R&D program management, research operations, structural biophysics, experimental design, data analysis, and communication across scientific, operational, leadership, and external\-review audiences\. Previously, Domarin advanced plant\-based egg development at JUST as both a Scientist II in Protein Chemistry and Senior R&D Program/Project Manager, connecting bench, pilot, manufacturing, and tech\-transfer work\. His research background includes a Ph\.D\. in Chemistry–Chemical Biology from UC Irvine and postdoctoral work in the National Cancer Institute’s Macromolecular NMR Section, where he studied E2:E3 ligase interactions and dynamics using NMR and complementary biophysical methods\.

## Services

- Program Management
- Isotopic labeling
- Data Analysis
- Research Skills
- Product Development
- Research and Development \(R&D\)
- Research Design
- Communication
- NMR Spectroscopy
- Light Scattering
- Protein\-protein Interactions
- Protein Structure
- Protein Expression
- Protein Purification
- Protein Characterization
- Molecular Cloning
- Gel Electrophoresis
- Circular Dichroism
- Fluorescence Spectroscopy
- Differential Refractometry

## Highlights

- Directs operations for AnimateIQ, Animate Biosciences' proprietary AI\-driven research platform, coordinating cross\-functional research teams from computational design to experimental validation within one\-month research cycles\.
- Maintains a living workstream\-status tracker and research\-initiative tracking for program milestones, experimental results, and next steps across active Animate Biosciences workstreams\.
- Manages five external CROs conducting preclinical studies across dermal, pulmonary, and liver therapeutic indications, including scoping, milestone tracking, and deliverable management\.
- Compiles and maintains research documentation for pre\-IND regulatory submissions and communicates findings to leadership and external reviewers\.
- Serves as operational chief of staff to Animate Biosciences' CEO, driving Gantt\-chart development, patent\-filing review, investment and technical deck design, and cross\-departmental goal tracking\.
- Led a laboratory move at JUST involving protein chemistry, molecular biology, and protein automation departments\.
- Designed biophysical experiments at JUST to support upstream and downstream plant\-based egg product development and improve mung bean protein extraction processes\.
- Used circular dichroism spectroscopy and differential scanning calorimetry to monitor mung bean protein secondary structure and thermostability\.
- Used SDS\-PAGE and size\-exclusion chromatography to observe protein size and complex formation at JUST\.
- Collaborated with chefs, food scientists, chemists, engineers, process scientists, and biologists at JUST to advance plant\-based egg development from bench to pilot and manufacturing scales\.
- Supported protein\-extraction trials at JUST's large\-scale manufacturing facility in Appleton, Minnesota, and product\-version trials at downstream co\-manufacturers\.
- Oversaw experimental design and data analysis for product\-development initiatives at JUST and presented R&D updates to senior leadership and executive team members\.
- Helped found JUST Network for Women and Allies, an employee resource group focused on empowering women and minorities\.
- Investigated protein\-protein interactions and dynamics of E2:E3 ligases as a National Cancer Institute postdoctoral fellow in the Macromolecular NMR Section Structural Biophysics Lab\.
- Used NMR for protein residue assignments, structure, and side\-chain dynamics, along with DSC, MST, DLS, CD spectroscopy, ESI\-MS, and SEC for protein characterization\.
- Conducted NMR\-based SAR studies, eye\-lens crystallin expression and characterization, and box jellyfish lens crystallin structure determination at UC Irvine\.
- Measured emission lifetimes from synthesized pyrene ligands for excimers and monomers as an undergraduate researcher at Whittier College\.

## Experience

- **Director Program Management at Animate Biosciences, Inc\.** (2025\-02\-01–present) — Directed operations for AnimateIQ, a proprietary AI\-driven research platform integrating frontier tools coordinated cross\-functional research teams and maintained a living tracker of workstream status, ensuring rapid iteration from computational design to experimental validation within one\-month research cycles Managed vendor relationships with 5 external CROs conducting pre\-clinical studies across multiple therapeutic indications \(dermal, pulmonary, liver\) oversaw scoping, milestone tracking, and deliverable management across the full research pipeline Compiled and maintained research documentation for pre\-IND regulatory submissions, communicating findings across multiple workstreams for leadership and external reviewers Served as operational chief\-of\-staff to the CEO: independently identified gaps in execution, proposed initiatives, and drove follow\-through across Gantt chart development, patent filing review, investment and technical deck design, and cross\-departmental goal tra
- **Director, Program Management at Animate Biosciences, Inc\.** (2025\-02\-01–present) — Directed operations for AnimateIQ, a proprietary AI\-driven research platform integrating frontier tools coordinated cross\-functional research teams and maintained a living tracker of workstream status, ensuring rapid iteration from computational design to experimental validation within one\-month research cycles Managed vendor relationships with 5 external CROs conducting pre\-clinical studies across multiple therapeutic indications \(dermal, pulmonary, liver\) oversaw scoping, milestone tracking, and deliverable management across the full research pipeline Compiled and maintained research documentation for pre\-IND regulatory submissions, communicating findings across multiple workstreams for leadership and external reviewers Served as operational chief\-of\-staff to the CEO: independently identified gaps in execution, proposed initiatives, and drove follow\-through across Gantt chart development, patent filing review, investment and technical deck design, and cross\-departmental goal tra
- **R&D Lab Manager at Animate Biosciences, Inc\.** (2024\-04\-01–2025\-02\-01)
- **Senior R&D Program/Project Manager at JUST** (2023\-01\-01–2024\-03\-01) — Collaborated cross\-functionally with all R&D groups \(chefs, food scientists, chemists, engineers, process scientists, and biologists\) to drive plant\-based egg development goals from bench to pilot to manufacturing scales for both raw material generation \(upstream\) and product production \(downstream\) Supported process sciences and tech transfer team towards the implementation of protein extraction trials at the large\-scale manufacturing facility in Appleton, MN Organized and assisted product developers and quality teams for product version trials at downstream co\-manufacturers Oversaw experimental design for product development initiatives while also delivering data analyses to ensure accurate data interpretation and efficient decision\-making Proactively managed project timelines through coordinated weekly meetings with team members and leadership in order to drive progress and meet milestones Facilitated effective communication amongst leadership and team members connecting all R
- **Scientist II, Protein Chemistry at JUST** (2021\-04\-01–2023\-01\-01) — Designed experiments using various biophysical tools to understand protein structure and function for both upstream and downstream product development Monitored protein secondary structure and thermostability using circular dichroism \(CD\) spectroscopy and differential scanning calorimetry \(DSC\), respectively, following changes in the mung bean protein extraction process Observed protein size and complex formation using a combination of SDS\-PAGE and size\-exclusion chromatography \(SEC\) Primarily focused on improvements in protein extraction processes by monitoring the native protein yield and functionality Worked on enhancing protein throughout the upstream and downstream processes by experimenting with food grade chemicals Used DSC to observe trends in thermostability amongst mung bean protein and food grade chemicals Communicated results and next steps with scientists and non\-scientists in all other egg development R&D teams, which helped establish collaboration on all future exp
- **Postdoctoral Fellow at National Cancer Institute \(NCI\)** (2017\-02\-01–2021\-03\-01) — Macromolecular NMR Section Structural Biophysics Lab Advisor: R\. Andrew Byrd, Ph\.D\. Investigated protein\-protein interactions and dynamics of E2:E3 ligases through protein structure techniques such as NMR for protein residue assignments, protein structure, and side\-chain dynamics\. In addition to NMR, I used other biophysical tools to characterize protein structure and functionality which included DSC, Microscale Thermophoresis \(MST\), dynamic light scattering \(DLS\), CD spectroscopy, electrospray ionization mass spectroscopy \(ESI\-MS\), and SEC\.
- **Graduate Student Researcher at UC Irvine** (2011\-09\-01–2016\-11\-01) — Chemistry – Chemical Biology Advisor: Professor Rachel W\. Martin SAR studies using NMR methodology protein expression and characterization of eye lens crystallins structure determination of box jellyfish lens crystallin\.
- **Undergraduate Student Researcher at Whittier College** (2010\-04\-01–2011\-05\-01) — Advisor: Professor Amy C\. Moskun Measured emission lifetimes from synthesized pyrene ligands for excimers and monomers
- **Supplemental Instructor at Whittier College** (2010\-01\-01–2011\-01\-01) — Quantitative Analysis Theory \(Department of Chemistry, Whittier College\) Calculus and Analytical Geometry II \(Department of Mathematics, Whittier, College\)
- **Center for Advising and Academic Success Tutor at Whittier College** (2007\-01\-01–2011\-01\-01) — Courses included Transition to College Mathematics, College Algebra Quantitative Reasoning, Elementary Statistics, Mathematics for the Management Sciences, Precalculus, Integrated Precalculus/Calculus, Calculus and Analytical Geometry I and II

## Education

- Doctor of Philosophy \(Ph\.D\.\), Chemistry \- Chemical Biology — University of California, Irvine (2011\-01\-01–2016\-01\-01)
- Bachelor of Arts \- BA, Economics — Whittier College (2007\-09\-01–2011\-05\-01)
- Bachelor of Arts \- BA, Economics — Whittier College (2007\-09\-01–2011\-05\-01)

## FAQ

### What does Domarin do now?

Domarin is Director of Program Management at Animate Biosciences, Inc\. He directs research operations for AnimateIQ, a proprietary AI\-driven research platform integrating frontier tools, and supports cross\-functional execution from computational design to experimental validation\.

### What are Domarin's strengths in program management and research operations?

Domarin coordinates cross\-functional research teams, maintains a living tracker of workstream status, and supports rapid iteration within one\-month research cycles\. He also tracks program milestones, experimental results, and next steps across active research workstreams\.

### What does Domarin manage with external CROs at Animate Biosciences?

At Animate Biosciences, Domarin manages vendor relationships with five external CROs conducting preclinical studies across dermal, pulmonary, and liver therapeutic indications\. His responsibilities include study scoping, milestone tracking, and deliverable management across the research pipeline\.

### What regulatory\-support work has Domarin performed?

Domarin compiles and maintains research documentation for pre\-IND regulatory submissions and communicates findings across workstreams for leadership and external reviewers\.

### How has Domarin supported the CEO at Animate Biosciences?

Domarin serves as an operational chief of staff to the CEO\. He identifies execution gaps, proposes initiatives, and drives follow\-through on Gantt\-chart development, patent\-filing review, investment and technical deck design, and cross\-departmental goal tracking he also represents the team as a primary cross\-functional contact\.

### What other role has Domarin held at Animate Biosciences?

Domarin also held the R&D Lab Manager role at Animate Biosciences, Inc\.

### What did Domarin do as a Scientist II in Protein Chemistry at JUST?

At JUST, Domarin was a Scientist II in Protein Chemistry\. He designed biophysical experiments for upstream and downstream product development, focusing on mung bean protein extraction, native protein yield, functionality, secondary structure, thermostability, size, and complex formation\.

### Which methods did Domarin use in protein chemistry at JUST?

Domarin monitored protein secondary structure with circular dichroism spectroscopy and thermostability with differential scanning calorimetry during changes to the mung bean protein extraction process\. He used SDS\-PAGE and size\-exclusion chromatography to observe protein size and complex formation, and used food\-grade chemicals to improve protein extraction and investigate thermostability trends\.

### What operational and communication contributions did Domarin make at JUST as a protein chemist?

Domarin communicated results and next steps with scientists and non\-scientists across egg\-development R&D teams, helping establish collaboration for future experiments and discoveries\. He also led a laboratory move involving protein chemistry, molecular biology, and protein automation departments, and presented experimental designs and scientific concepts to larger audiences\.

### What did Domarin do as Senior R&D Program/Project Manager at JUST?

As Senior R&D Program/Project Manager at JUST, Domarin collaborated with chefs, food scientists, chemists, engineers, process scientists, and biologists to advance plant\-based egg development from bench to pilot to manufacturing scales\. His work covered both upstream raw\-material generation and downstream product production\.

### How did Domarin support manufacturing and tech transfer at JUST?

Domarin supported process sciences and tech\-transfer teams implementing protein\-extraction trials at JUST's large\-scale manufacturing facility in Appleton, Minnesota\. He also organized and assisted product developers and quality teams with product\-version trials at downstream co\-manufacturers\.

### How did Domarin manage product\-development programs at JUST?

Domarin oversaw experimental design for product\-development initiatives and delivered data analyses to support accurate interpretation and efficient decisions\. He managed timelines through weekly meetings with team members and leadership, facilitated communication across R&D and product\-development work, and presented updates to senior leadership and executive team members\.

### What collaboration and inclusion work did Domarin contribute at JUST?

Domarin fostered open communication, knowledge sharing, and collaboration that integrated scientific expertise with engineering principles for egg\-based product development and tech transfer\. He also helped found JUST Network for Women and Allies, an employee resource group focused on empowering women and minorities, with several female colleagues\.

### What was Domarin's postdoctoral research at the National Cancer Institute?

At the National Cancer Institute's Macromolecular NMR Section Structural Biophysics Lab, Domarin was a Postdoctoral Fellow advised by R\. Andrew Byrd, Ph\.D\. He investigated protein\-protein interactions and dynamics of E2:E3 ligases\.

### Which biophysical techniques has Domarin used?

Domarin used NMR for protein residue assignments, protein structure, and side\-chain dynamics\. He also used differential scanning calorimetry, microscale thermophoresis, dynamic light scattering, circular dichroism spectroscopy, electrospray ionization mass spectrometry, and size\-exclusion chromatography to characterize protein structure and functionality\.

### What did Domarin research as a graduate student at UC Irvine?

As a Graduate Student Researcher in UC Irvine's Chemistry–Chemical Biology program, advised by Professor Rachel W\. Martin, Domarin conducted SAR studies using NMR methodology, expressed and characterized eye\-lens crystallins, and determined the structure of a box jellyfish lens crystallin\.

### What was Domarin's undergraduate research at Whittier College?

As an Undergraduate Student Researcher at Whittier College, advised by Professor Amy C\. Moskun, Domarin measured emission lifetimes from synthesized pyrene ligands for excimers and monomers\.

### What courses did Domarin tutor at Whittier College?

Domarin was a Center for Advising and Academic Success Tutor at Whittier College\. He tutored Transition to College Mathematics, College Algebra Quantitative Reasoning, Elementary Statistics, Mathematics for the Management Sciences, Precalculus, Integrated Precalculus/Calculus, and Calculus and Analytical Geometry I and II\.

### What did Domarin do as a Supplemental Instructor at Whittier College?

Domarin also served as a Supplemental Instructor at Whittier College for Quantitative Analysis Theory in the Chemistry Department and Calculus and Analytical Geometry II in the Mathematics Department\.

## Links

- LinkedIn: https://www\.linkedin\.com/in/domarin

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